Bio Ceramics

Other Applications

Bio Functional Coatings

Research into TriCalcium Phosphate’ pharma and orthopedic applications is in it’s infancy. A few remarkable pieces of research are noted here for your consideration:
Biofunctionalization of metallic implants by calcium phosphate coatings https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529680/" Abstract:
Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability. Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions. Calcium phosphates (CaPs) are the major inorganic component of bone tissues, and thus owning inherent biocompatibility and osseointegration properties. As such, they have been widely used in clinical orthopedics and dentistry. The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs. This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings. We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances, and then give insight into the representative biofunctions, i.e. osteointegration, corrosion resistance and biodegradation control, and antibacterial property, provided by CaP coatings for metallic implant materials.
Polycaprolactone coated porous tricalcium phosphate scaffolds for controlled release of protein for tissue engineering https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058418/ Abstract
Polycaprolactone (PCL) was coated on porous tricalcium phosphate (TCP) scaffolds to achieve controlled protein delivery. Porous TCP scaffolds were fabricated using reticulated polyurethane foam as sacrificial scaffold with a porosity of 70–90 vol %. PCL was coated on sintered porous TCP scaffolds by dipping-drying process. The compressive strength of TCP scaffolds increased significantly after PCL coating. The highest strength of 2.41 MPa at a porosity of 70% was obtained for the TCP scaffold coated with 5% PCL solution. Model protein bovine serum albumin (BSA) was encapsulated efficiently within the PCL coating. The amount of BSA encapsulation was controlled by varying proteins’ composition in the PCL coating. The FTIR analysis confirmed that BSA retained its structural conformation and did not show significant denaturization during PCL coating. The release kinetics in phosphate buffer solution indicated that the protein release was controlled and sustained, and primarily dependant on protein concentration encapsulated in the PCL coating.
Effects of Tricalcium Phosphate Coated Titanium on Adjacent Early Bone Formation Bristol Williams University of Tennessee Health Science Center https://dc.uthsc.edu/cgi/viewcontent.cgi?referer=https://www.google.com/&httpsredir=1&article=1294&context=dissertations Abstract
Dental implants are the gold standard of restorative dentistry today. Implants have been used for several years in Orthopedics. Dental implants are an important treatment option for several patients today. When a patient is fully or partially dentate, they are given the opportunity to restore their dentition in ways similar to their natural oral cavity. The past literature states that titanium is one of the first metals used in implant placement. There have been many improvements made on this material. Most modifications have been used in order to promote more bone growth around these implants. Several different coating materials have been used to increase bone formation. Titanium (Ti) surfaces have been coated with hydroxyapatite (HA), plasma spray, and several blasting techniques have been implemented. Tricalcium phosphate (TCP) is a coating that has been used for several years. Due to its porosity and likeness to natural bone, many feel that it is an ideal coating for both dental and orthopedic titanium implants. We believe that TCP coated titanium increases the amount of osteoblastic cell attachment and early bone producing biomarker proteins in osteoblastic cells when compared to HA coated titanium and titanium only materials.

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